Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :PF-431396717906-29-1HY-10460506.50C22H21F3N6O3S>98%Solubility:DMSOSOMechanisms: Pathways:Protein Tyrosine Kinase/RTK; Target:Pyk2 Pathways:Protein Tyrosine Kinase/RTK; Target:FAK Pathways:TGF-beta/Smad; Target:Pyk2 Biological Activity:PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor(IC50 values are 2 and 11 nM respectively). PF-431396 promotes osteoblast recruitment andactivity, and stimulates bone formation in ovariectomized rats. PF-431396 is used in treatment ofosteoporosis.References:[1]. Buckbinder, Leonard et al. Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells andbone formation, and offers an anabolic treatment approach for osteoporosis. Proceedings of theNational Academy of Sciences of the United States of America(2007), 04(25), 10619-10624. [2]. Tse KW, Dang-Lawson M, Lee RL, Vong D, Bulic A, Buckbinder L, Gold MR.B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPasesand is required for B cell spreading.J Biol Chem. 2009 Aug 21;284(34):22865-77. Epub 2009 Jun26. [3]. Han S, Mistry A, Chang JS, Cunningham D, Griffor M, Bonnette PC, Wang H, Chrunyk BA,Aspnes GE, Walker DP, Brosius AD, Buckbinder L.Structural characterization of proline-rich tyrosinekinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design.J Biol Chem.2009 Ma...Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com 18 Wilkinson Way, Princeton, NJ 08540,USAEmail: info@medchemexpress.com Web: www.medchemexpress.com
