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专利名称：Process for the preparation of substituted
chloroacetanilides
发明人：Ferenc Mogyorodi,Eniko Koppany,Tibor
Bodi,Karoly Balogh,Istvan Toth,RezsoBognar,Sandor Makleit,Gyorgy Litkei,MiklosRakosi,Zoltan Dinya
申请号：US06/456383申请日：19830107公开号：US04511736A公开日：19850416
摘要：The invention relates to a novel process for preparing chloroacetanilides of theformula ##STR1## wherein: R.sub.1 and R.sub.2 represent independently from each othera hydrogen atom or a C.sub.1-8 alkyl or C.sub.1-8 alkoxy group; and
R.sub.3 stands for a straight chained or branched C.sub.1-8 alkoxy group.
Said process is characterized by chloroacetylating a 2,6-dialkylaniline of the formula##STR2## wherein R.sub.1 and R.sub.2 are as defined above, at a temperature of 10° to120° C., optionally in a solvent medium in the presence of an acid binding agent, thenreacting a thus- obtained intermediate with chloromethyl chloroformiate or,alternatively, reacting a compound of the formula (II) first with chloromethylchloroformiate and subjecting then to chloroacetylation, thereafter reacting a thus-obtained intermediate with an alcohol of the formula ##EQU1## wherein R.sub.3 is asdefined above, optionally in a solvent medium in the presence of an acid binding agent,and recovering a product of the formula (I) in a known manner.
The process of the invention enables the more simple and economic preparation ofthe compounds of formula (I) of improved purity.
申请人：ESZAKMAGYARORSZAGI VEGYIMUVEK
代理人：Karl F. Ross,Herbert Dubno
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